This report describes the rationale, approaches, organization, and resource development leading to a large-scale deletion bin map of the hexaploid wheat genome. Accompanying reports in this issue detail results from chromosome bin-mapping of expressed sequence tags representing genes onto the seven homoeologous chromosome groups and a global analysis of the entire mapped wheat EST data set. Among the resources developed were the first extensive public wheat EST collection. Described are protocols for sequencing, sequence processing, EST nomenclature, and the assembly of (...) ESTs into contigs. These contigs plus singletons were used for selection of distinct sequence motif unigenes. Selected ESTs were rearrayed, validated by 5′ and 3′ sequencing, and amplified for probing a series of wheat aneuploid and deletion stocks. Images and data for all Southern hybridizations were deposited in databases and were used by the coordinators for each of the seven homoeologous chromosome groups to validate the mapping results. Results from this project have established the foundation for future developments in wheat genomics. (shrink)

Teaching business ethics to undergraduates has disclosed difficulties for both students and teacher which raise deeper issues about what is the purpose of teaching ethics and of engaging in business. The author is Lecturer in Business Ethics in the Faculty of Business and Social Studies, Cheltenham & Gloucester College of Higher Education, Swindon Road, Cheltenham, Glos GL50 4AZ, UK.

A psychology, Phenomenology and ontology of creativity developed by this french epistemologist and historian of science (1884-1962) are systematically described. Starting from analysis of image networks in literature, Bachelard presents imagination as autonomous, A power of human transcendence, A force preceding perception and memory. He ultimately surpasses psychological reductionism. Imagination of form is inferior to imagination of matter (depth); yet they both are secondary to dynamic imagination. Bachelard's fundamental method is a phenomenological study of images as origins of consciousness; a (...) phenomenology of reverie and writing underlies his ontology. Reverie is the model upon which imaginative consciousness is judged. Man should extend the freedom and beauty of his inner cosmos to enhance relation with the world. (shrink)

Bachelard’s works on imagination have been used primarily by literary critics interested in the archetypal imagery of writers. His treatment of the imagination of matter has led to a method of classifying poets according to their favorite substances, based on a view of Bachelard as a “psychoanalyst” of the elements. But the phenomena of imagination, the images themselves, are not his fundamental concern. Bachelard’s physics and chemistry of imagination also imply a metaphysics. Definition of the contents and function of imagination (...) illustrating a philosophy of imagination in itself is the purpose of the present essay. (shrink)

Jules Michelet Historian, Philosopher, Naturalist A vast, all-embracing literary personality dominates Michelet's works: that of the author. ...

Biobanks are increasingly being created specifically for research purposes. Concomitantly, we are seeing significant and evolving shifts in research ethics in relation to biobanking. Three discrete shifts are identified in this article. The first extends the ethical focus beyond the protection of human subjects to the promotion of broader community benefits of research utilizing biobanked resources, and an expectation that these benefits will be shared. The second involves the evolution of the traditional consent paradigm for future research uses of biobanks (...) resources that are not in contemplation at the time of donation. The third involves a move away from single project management to more dynamic governance accountability to research participants and the public. These shifts may take different local and institutional forms but share common recognizable elements. (shrink)

RAID-II is a high-bandwidth, network-attached storage server designed and implemented at the University of California at Berkeley. In this paper, we measure the performance of RAID-II and evaluate various architectural decisions made during the design process. We first measure the end-to-end performance of the system to be approximately 20 MB/s for both disk array reads and writes. We then perform a bottleneck analysis by examining the performance of each individual subsystem and conclude that the disk subsystem limits performance. By adding (...) a custom interconnect board with a high-speed memory and bus system and parity engine, we are able to achieve a performance speedup of 8 to 15 over a comparative system using only off-the-shelf hardware. (shrink)

Probability is not an unambiguous concept within the sciences or in vernacular language, yet it is fundamental to much of behavior analysis. The present paper examines some problems this ambiguity creates in general,as well as within the experimental analysis of behavior, in particular. As background material, we first introduce the three most common theories of probability in mathematics and science, discussing their advantages and disadvantages, and their relevance to behavior analysis. Next, we discuss the concept of probability as encountered in (...) the writings of B.F. Skinner and in the contemporary behavior analysis more generally, the latter being based on material drawn from the professional literature and from a questionnaire survey. Although the exercise is basically a descriptive one, we do conclude with some suggestions that may promote more effective action on those occasions when behavior analysts speak of "probability.". (shrink)

A primary proposal of the Cowan target article is that capacity limits arise in working memory because only 4 chunks of information can be attended at one time. This implies a single, unitary attentional focus or resource; we instead propose that relatively independent attentional mech- anisms operate within different cognitive subsystems depending on the demands of the current stimuli and tasks.

The capacity of visual working memory (VWM) refers to the amount of visual information that can be maintained in mind at once, readily accessible for ongoing tasks. In healthy young adults, the capacity limit of VWM corresponds to about three simple objects. While some researchers argued that VWM capacity becomes adult-like in early years of life, others claimed that the capacity of VWM continues to develop beyond middle childhood. Here we assessed whether VWM capacity reaches adult levels in adolescence. Using (...) an adaptation of the visual change detection task, we measured visual working memory capacity estimates in 13 year-olds, 16-year-olds, and young adults. We tested whether the capacity estimates observed in early or later years of adolescence were comparable to the estimates obtained from adults. Our results demonstrated that the capacity of VWM continues to develop throughout adolescence, not reaching adult levels even in 16 year-olds. These findings suggest that VWM capacity displays a prolonged development, similar to the protracted trajectories observed in various other aspects of cognition. (shrink)

In the mouse, at least 16 genes regulate vesicle trafficking to specialized lysosome‐related organelles, including platelet dense granules and melanosomes. Fourteen of these genes have been identified by positional cloning. All 16 mouse mutants are models for the genetically heterogeneous human disease, Hermansky–Pudlak Syndrome (HPS). Five HPS genes encode known vesicle trafficking proteins. Nine genes are novel, are found only in higher eukaryotes and encode members of three protein complexes termed BLOCs (Biogenesis of Lysosome‐related Organelles Complexes). Mutations in murine HPS (...) genes, which encode protein co‐members of BLOCs, produce essentially identical phenotypes. In addition to their well‐known effects on pigmentation, platelet function and lysosome secretion, HPS genes control a wide range of physiological processes including immune recognition, neuronal functions and lung surfactant trafficking. Studies of the molecular functions of HPS proteins will reveal important details of vesicle trafficking and may lead to therapies for HPS. BioEssays 26:616–628, 2004. © 2004 Wiley Periodicals, Inc. (shrink)